Current release of Sequedex Version 2 comes with two data modules: Life2550-8GB.1 and virus10k.1. To install an additional data module, simply put it in the data subdirectory of the sequedex executable directory. All data module files have extension .jar. Putting anything other than a data module in the data directory will currently result in an error when running Sequedex. All current data modules are of two types 1) Life2550 These modules are based on a full Tree of Life including bacteria, archaea, and eukaryotes with classifications from SEED (www.theseed.org). There are multiple versions of Life2550 modules, representing the same tree of life but with varying numbers of signatures in order to allow Sequedex to run over a range of available RAM: from 4 gb to 40 gb (for the full set of signatures). The amount of available RAM required is in the modules name (e.g. Life2550-8GB.1). The size of the module on disk is much smaller than the amount of RAM required. If a particular module is selected and the computer does not have enough RAM available, Sequedex will warn the user. Life2550-8GB.1 also includes classifications from PFAM 31.0 (pfam.xfam.org); 2) virus10k This module is based on a tree of viruses of all types (but excluding pages) with classification from PFAM 31.0 (pfam.xfam.org). To remove a module from Sequedex, simply delete it from the data directory. Data modules are released under Los Alamos National Laboratory LA-UR-18-31119 and may be downloaded from https://sequedex.lanl.gov/dataModules. J. Cohn Dec 2018